Phenotypic Alterations of Dendritic Cells Are Involved in Suppressive Activity of Trichosanthin-Induced CD8+CD28− Regulatory T Cells
نویسندگان
چکیده
منابع مشابه
Phenotypic alterations of dendritic cells are involved in suppressive activity of trichosanthin-induced CD8+CD28- regulatory T cells.
The nature and differentiation of regulatory CD8(+)CD28(-) T cells are poorly understood. In this study, we demonstrate that native Ag trichosanthin (Tk), a highly purified linear peptide isolated from a Chinese medicinal herb, is able to induce strong suppression of OVA-specific lymphoproliferation at low concentrations via activation of IL-4/IL-10-secreting CD8(+)CD28(-) regulatory T cells (T...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2010
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.0901488